Depot^* former

Consistent drug deposition

A depot is typically placed under the skin or into a muscle, where it deposits the drug in a small, localized area. The drug is gradually absorbed by surrounding tissue. This allows the active compound to be released in a consistent way over an extended period of time, improving patient compliance.

BioSustane SAIB NF is an excellent lipophilic depot former. It’s extensively metabolized in the body into sucrose and partially acylated sucrose. Both are readily absorbed and subsequently eliminated from the body. Release times can vary from a few days to a month or more.

Figure 1. Mechanism of release of API from BioSustane depot

BioSustane prevents recrystallization of poorly water-soluble APIs. When used as carrier for an amorphous solid dispersion, BioSustane forms a stable dispersion. A study of several weeks of aprepitant formulation with BioSustane through X-ray diffraction revealed no peaks, indicating BioSustane forms a stable, amorphous solid dispersion that inhibits API recrystallization

Concept: Consider a solution containing BioSustane, solvent, active pharmaceutical ingredients (APIs) and optional additives. The small amount of solvent diffuses into surrounding tissue or interstitial fluid and leaves behind a highly viscous depot. There is delayed release of active ingredients.

The breakdown rate of the depot can be slowed through an additive like a biodegradable polymer.  

_{*Eastman Chemical Company does not manufacture or market an injectable grade of BioSustane™ SAIB NF excipient. It is the responsibility of our customers to determine that their use of our product(s) is safe, lawful and technically suitable in their intended applications.}