Sustained release

Stable product dissolutions

BioSustane SAIB NF can be used as a matrix former for the sustained release of hydrophobic (poorly water soluble) and hydrophilic (water soluble) active pharmaceutical ingredients (APIs).

BioSustane is nonpolymeric and does not suffer much from batch-to-batch manufacturing variation, ensuring stable product dissolution, which is often challenging with polymer matrix formers. When used as a sustained-release excipient, BioSustane imparts abuse deterrence to the dosage form. 

Figure 1. Dissolution of a formulation containing BioSustane, formulated with diclofenac sodium and other excipients

Sustained release of the API is achieved, and the release can be tuned with varying amounts of BioSustane in the formulation.